Although ensuring that calves have APT is the most significant management factor to ensure the health of neonatal calves on calf ranches, colostrum supplementation during the first 2 wk of life in calves was effective in reducing diarrheal disease and the use of antimicrobials. The ADG up to 4 wk of age in colostrum-supplemented calves was significantly greater compared with that in control calves, likely because of a combination of greater energy intake through the liquid feed, increased grain intake, and fewer days with diarrhea.